New insights into the biology and pathology of the cutaneous lymphatic system.
Identifieur interne : 008749 ( Main/Exploration ); précédent : 008748; suivant : 008750New insights into the biology and pathology of the cutaneous lymphatic system.
Auteurs : Satoshi Hirakawa [États-Unis] ; Michael DetmarSource :
- Journal of dermatological science [ 0923-1811 ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Facteur de croissance endothéliale vasculaire de type A (génétique), Facteur de croissance endothéliale vasculaire de type A (métabolisme), Facteurs de croissance endothéliale (génétique), Homéostasie, Humains, Lymphangiogenèse (génétique), Lymphoedème (génétique), Marqueurs biologiques, Peau (métabolisme), Récepteurs aux facteurs de croissance endothéliale vasculaire (génétique), Récepteurs aux facteurs de croissance endothéliale vasculaire (métabolisme), Système lymphatique (métabolisme), Vaisseaux lymphatiques (métabolisme).
- MESH :
- génétique : Facteur de croissance endothéliale vasculaire de type A, Facteurs de croissance endothéliale, Lymphangiogenèse, Lymphoedème, Récepteurs aux facteurs de croissance endothéliale vasculaire.
- métabolisme : Facteur de croissance endothéliale vasculaire de type A, Peau, Récepteurs aux facteurs de croissance endothéliale vasculaire, Système lymphatique, Vaisseaux lymphatiques.
- Animaux, Homéostasie, Humains, Marqueurs biologiques.
English descriptors
- KwdEn :
- Animals, Biomarkers, Endothelial Growth Factors (genetics), Homeostasis, Humans, Lymphangiogenesis (genetics), Lymphatic System (metabolism), Lymphatic Vessels (metabolism), Lymphedema (genetics), Receptors, Vascular Endothelial Growth Factor (genetics), Receptors, Vascular Endothelial Growth Factor (metabolism), Skin (metabolism), Vascular Endothelial Growth Factor A (genetics), Vascular Endothelial Growth Factor A (metabolism).
- MESH :
- chemical , genetics : Endothelial Growth Factors, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A.
- chemical , metabolism : Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A.
- chemical : Biomarkers.
- genetics : Lymphangiogenesis, Lymphedema.
- metabolism : Lymphatic System, Lymphatic Vessels, Skin.
- Animals, Homeostasis, Humans.
Abstract
The cutaneous lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, in the afferent phase of the immune response, and in the metastatic spread of skin cancers. The recent identification of genes that specifically control lymphatic development and the growth of lymphatic vessels (lymphangiogenesis), together with the discovery of new lymphatic endothelium-specific markers have now provided new insights into the molecular mechanisms that control lymphatic development and function. These scientific advances have also led to a new understanding of the genetic basis of several hereditary diseases that are associated with lymphedema, and they have provided surprising evidence that malignant tumors can directly promote lymphangiogenesis and lymphatic metastasis.
DOI: 10.1016/j.jdermsci.2003.10.006
PubMed: 15194141
Affiliations:
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Le document en format XML
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Endothelial Growth Factor</term><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphangiogenesis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term><term>Facteurs de croissance endothéliale</term><term>Lymphangiogenèse</term><term>Lymphoedème</term><term>Récepteurs aux facteurs de croissance endothéliale vasculaire</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphatic System</term><term>Lymphatic Vessels</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type A</term><term>Peau</term><term>Récepteurs aux facteurs de croissance endothéliale vasculaire</term><term>Système lymphatique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Homeostasis</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Homéostasie</term><term>Humains</term><term>Marqueurs biologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cutaneous lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, in the afferent phase of the immune response, and in the metastatic spread of skin cancers. The recent identification of genes that specifically control lymphatic development and the growth of lymphatic vessels (lymphangiogenesis), together with the discovery of new lymphatic endothelium-specific markers have now provided new insights into the molecular mechanisms that control lymphatic development and function. These scientific advances have also led to a new understanding of the genetic basis of several hereditary diseases that are associated with lymphedema, and they have provided surprising evidence that malignant tumors can directly promote lymphangiogenesis and lymphatic metastasis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Hirakawa, Satoshi" sort="Hirakawa, Satoshi" uniqKey="Hirakawa S" first="Satoshi" last="Hirakawa">Satoshi Hirakawa</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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